Dr Xi May Zhen1,2,3,4, Prof Jencia Wong1,2, Amanda Gauld1, Stephanie Noonan1, Maria Constantino1, Arianne Sweeting1,2, Anna-Jane Harding1, Dr Adam Mackie5, Dr Hend Chatila5, Prof Stephen Twigg1,2, Dr Timothy Middleton1, Dr Margaret McGill1,2, Dr Ted Wu1, Associate Professor Glynis Ross1,2
1Department Of Endocrinology, Royal Prince Alfred Hospital, Sydney, Australia, 2Central Clinical School, Faculty of Medicine and Health, University of Sydney , Sydney, Australia, 3Department of Diabetes and Endocrinology, Blacktown Hospital, Sydney, Australia, 4School of Medicine, Western Sydney University, Sydney, Australia, 5Women and Babies, Royal Prince Alfred Hospital, Sydney, Australia
Biography:
Biographies to come
Abstract:
Background and aims: In the context of the varying age cut-offs that have been proposed for young-onset type 2 diabetes mellitus (YT2DM), we examined whether pregnancy outcomes differ between women diagnosed with YT2DM at < 30 years versus women with YT2DM diagnosed at 30 to < 40 years.
Methods: We performed a retrospective analysis of data from women with pre-gestational YT2DM who presented for their initial antenatal diabetes clinic visit at the Royal Prince Alfred Hospital (Sydney) between 2010-2019. Primary outcomes included the rates of large-for-gestational age (LGA) infants, macrosomia, and pre-eclampsia. Baseline characteristics and pregnancy outcomes were compared between women with YT2DM diagnosed at < 30 years versus those diagnosed at 30 to < 40 years.
Results: Compared to those diagnosed with YT2DM at 30 to < 40 years (n=69), the women diagnosed with YT2DM at < 30 years (n=66) had significantly longer duration of diabetes and higher rates of smoking during pregnancy (p < 0.05 for both). Those diagnosed with YT2DM at < 30 years also had higher rates of significant proteinuria and pre-eclampsia (p < 0.05 for both). The rates of LGA infants, macrosomia, and other pregnancy outcomes were similar between the two subgroups of women with YT2DM.
Conclusions: We found significantly higher rates of proteinuria and pre-eclampsia in the women diagnosed with YT2DM at < 30 years compared to those diagnosed at 30 to < 40 years, though this appeared to be at least partially driven by the longer duration of diabetes in the former group. Larger-scale studies are required to confirm whether women diagnosed with YT2DM at < 30 years are at even higher risk of adverse pregnancy outcomes compared to those diagnosed at 30 to < 40 years.
Keywords
young-onset type 2 diabetes, diabetes in pregnancy